Tetrahydrocurcumin protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis

• Tetrahydrocurcumin (THC) improves glucose and lipid metabolism disorders in nonalcoholic fatty liver disease (NAFLD) mice. THC regulates the expression of oxidoreductase genes lipid-metabolizing enzyme NAFLD increases antioxidant capacity inhibits deposition HepG2 cells by activating NRF2 signaling pathway. Nonalcoholic is most common metabolic world. In this study we investigated effect tetrahydrocurcumin (THC), a potent antioxidant, on NAFLD. We found that significantly reduced body weight, serum lipids, malondialdehyde (MDA) fasting blood (FBG) male mice induced feeding high-fat diet (HFD) for 8 weeks. A RNA-seq analysis revealed also affected many involved mice, including increasing mRNA CYP51 FOXQ1 . Moreover, sodium oleate-induced accumulation, activated pathway, up-regulated FGF21 cells. Overall, our showed can improve liver, which suggests dietary may be used to treat